Cracking the epitranscriptome
Open Access
- 19 January 2016
- journal article
- review article
- Published by Cold Spring Harbor Laboratory in RNA
- Vol. 22 (2), 169-174
- https://doi.org/10.1261/rna.054502.115
Abstract
Over 100 distinct chemical modifications can be catalyzed on RNA post-synthesis, potentially serving as a post-transcriptional regulatory layer of gene expression. This review focuses on recent advances, knowledge gaps, and challenges pertaining to N6-methyladenosine (m6A), an abundant modification of mRNA for which substantial progress has been made in recent years. The discussed aspects are also very relevant for a wide range of additional modifications on mRNA collectively coined the epitranscriptome.Keywords
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