Association between the TNFα‐308 A/G polymorphism and the onset‐age of Alzheimer disease
- 31 May 2002
- journal article
- research article
- Published by Wiley in American Journal of Medical Genetics
- Vol. 114 (5), 574-577
- https://doi.org/10.1002/ajmg.10515
Abstract
Local inflammatory processes associated with amyloid plaques would contribute to the progression of late‐onset Alzheimer disease (LOAD). Tumor necrosis factors α (TNFα) and β (LTα) are inflammatory cytokines involved in the local immune response occurring in the central nervous system of LOAD patients. Genetic variation at these genes could contribute to the risk of developing AD or influence the age at the onset of the disease. We genotyped 315 LOAD patients and 400 healthy controls for DNA‐polymorphisms in the genes encoding TNFα (‐308 G/A, ‐238G/A) and LTα (Asn26Thr). Carriers of ‐308A showed a mean age at onset 3 years younger than noncarriers of this allele (P = 0.019). Our data suggest an effect of the TNFα‐308 polymorphism on the age at onset of late AD. This represents additional evidence of the importance of genetic variation at the proinflammatory components in the origin and progression of this common neurodegenerative disease.Keywords
Funding Information
- The Spanish Fondo de Investigaciones Sanitarias (FIS-2000/0239 (to V.A.))
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