Current status of corneal collagen cross‐linking for keratoconus: a review
- 1 March 2013
- journal article
- review article
- Published by Taylor & Francis Ltd in Clinical and Experimental Optometry
- Vol. 96 (2), 155-164
- https://doi.org/10.1111/cxo.12020
Abstract
Over the past decade, corneal collagen cross-linking has become commonplace as a treatment option for individuals with progressive keratoconus. This is based on laboratory data suggesting that cross-linking using riboflavin and ultraviolet-A irradiation increases collagen diameter and the biomechanical strength of the treated cornea. Case series and limited randomised controlled trials support these findings with data demonstrating that cross-linking slows and possibly halts the progression of keratoconus. In some patients cross-linking results in an improvement in maximum corneal curvature, visual acuity, spherical equivalent and higher-order aberrations. The number of reported complications is small. More recently, variations in the treatment protocol have been described, although they have not yet been subject to comparative studies. While the published data indicate cross-linking is effective in modifying the natural history of keratoconus, the long-term impact of this treatment is still unknown. This paper reviews the theoretical basis, pre-clinical research and clinical results of corneal collagen cross-linking in keratoconus.Keywords
This publication has 89 references indexed in Scilit:
- Morphological and functional correlations in riboflavin UV A corneal collagen cross‐linking for keratoconusActa Ophthalmologica, 2012
- Corneal Collagen Cross-linking With Riboflavin and Ultraviolet-A Irradiation in Patients With Thin CorneasAmerican Journal of Ophthalmology, 2012
- Corneal Endothelial Damage After Collagen Cross-Linking TreatmentCornea, 2011
- Age-Related Long-Term Functional Results after Riboflavin UV A Corneal Cross-LinkingJournal of Ophthalmology, 2011
- Corneal melting after collagen cross-linking for keratoconus: a case reportJournal of Medical Case Reports, 2011
- Mechanisms of Corneal Tissue Cross-linking in Response to Treatment with Topical Riboflavin and Long-Wavelength Ultraviolet Radiation (UVA)Investigative Ophthalmology & Visual Science, 2010
- Keratitis and Corneal Scarring After UVA/Riboflavin Cross-linking for KeratoconusJournal of Refractive Surgery, 2009
- Corneal Healing After Riboflavin Ultraviolet-A Collagen Cross-Linking Determined by Confocal Laser Scanning Microscopy In Vivo: Early and Late ModificationsAmerican Journal of Ophthalmology, 2008
- Keratocyte cytotoxicity of riboflavin/UVA-treatment in vitroEye, 2004
- Increased resistance of crosslinked cornea against enzymatic digestionCurrent Eye Research, 2004