Effect of Diet and Exercise, Alone or Combined, on Weight and Body Composition in Overweight‐to‐Obese Postmenopausal Women
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Open Access
- 1 August 2012
- Vol. 20 (8), 1628-1638
- https://doi.org/10.1038/oby.2011.76
Abstract
Lifestyle interventions for weight loss are the cornerstone of obesity therapy, yet their optimal design is debated. This is particularly true for postmenopausal women; a population with a high prevalence of obesity yet toward whom fewer studies are targeted. We conducted a year‐long, 4‐arm randomized trial among 439 overweight‐to‐obese postmenopausal sedentary women to determine the effects of a calorie‐reduced, low‐fat diet (D), a moderate‐intensity, facility‐based aerobic exercise program (E), or the combination of both interventions (D+E), vs. a no‐lifestyle‐change control (C) on change in body weight and composition. The group‐based dietary intervention had a weight‐reduction goal of ≥10%, and the exercise intervention consisted of a gradual escalation to 45‐min aerobic exercise 5 day/week. Participants were predominantly non‐Hispanic whites (85%) with a mean age of 58.0 ± 5.0 years, a mean BMI of 30.9 ± 4.0 kg/m2 and an average of 47.8 ± 4.4% body fat. Baseline and 12‐month weight and adiposity measures were obtained by staff blinded to participants' intervention assignment. Three hundred and ninety nine women completed the trial (91% retention). Using an intention‐to‐treat analysis, average weight loss at 12 months was −8.5% for the D group (P < 0.0001 vs. C), −2.4% for the E group (P = 0.03 vs. C), and −10.8% for the D+E group (P < 0.0001 vs. C), whereas the C group experienced a nonsignificant −0.8% decrease. BMI, waist circumference, and % body fat were also similarly reduced. Among postmenopausal women, lifestyle‐change involving diet, exercise, or both combined over 1 year improves body weight and adiposity, with the greatest change arising from the combined intervention.Keywords
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