Biochemical Mechanism of Lipid-induced Impairment of Glucose-stimulated Insulin Secretion and Reversal with a Malate Analogue
Open Access
- 1 June 2004
- journal article
- Published by Elsevier BV
- Vol. 279 (26), 27263-27271
- https://doi.org/10.1074/jbc.m401167200
Abstract
No abstract availableKeywords
This publication has 46 references indexed in Scilit:
- Palmitate Inhibition of Insulin Gene Expression Is Mediated at the Transcriptional Level via Ceramide SynthesisJournal of Biological Chemistry, 2003
- Minireview: Secondary -Cell Failure in Type 2 Diabetes--A Convergence of Glucotoxicity and LipotoxicityEndocrinology, 2002
- Metabolic consequence of long-term exposure of pancreatic β cells to free fatty acid with special reference to glucose insensitivityBiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2002
- Overexpression of a Modified Human Malonyl-CoA Decarboxylase Blocks the Glucose-induced Increase in Malonyl-CoA Level but Has No Impact on Insulin Secretion in INS-1-derived (832/13) β-CellsJournal of Biological Chemistry, 2001
- Fatty acid-induced beta cell hypersensitivity to glucose. Increased phosphofructokinase activity and lowered glucose-6-phosphate content.JCI Insight, 1998
- Fatty Acids Rapidly Induce the Carnitine Palmitoyltransferase I Gene in the Pancreatic β-Cell Line INS-1Published by Elsevier BV ,1997
- Contribution of various substrates to total citric acid cycle flux and ]anaplerosis as determined by13C isotopomer analysis and O2 consumption in the heartMagnetic Resonance Materials in Physics, Biology and Medicine, 1996
- Pancreatic β-Cells in ObesityJournal of Biological Chemistry, 1995
- Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle.JCI Insight, 1994
- Establishment of 2-mercaptoethanol-dependent differentiated insulin- secreting cell linesEndocrinology, 1992