Scleroderma, Fasciitis, and Eosinophilia Associated with the Ingestion of Tryptophan

Abstract

An association between the ingestion of tryptophan and a syndrome characterized by scleroderma-like skin abnormalities, fasciitis, and eosinophilia has recently been recognized in the United States. We report the clinical and histopathological findings in nine patients and the results of biochemical analyses of tryptophan metabolism in seven patients with this syndrome.