Evolution of gene expression in the Drosophila melanogaster subgroup
- 27 January 2003
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Genetics
- Vol. 33 (2), 138-144
- https://doi.org/10.1038/ng1086
Abstract
Little is known about broad patterns of variation and evolution of gene expression during any developmental process. Here we investigate variation in genome-wide gene expression among Drosophila simulans, Drosophila yakuba and four strains of Drosophila melanogaster during a major developmental transition--the start of metamorphosis. Differences in gene activity between these lineages follow a phylogenetic pattern, and 27% of all of the genes in these genomes differ in their developmental gene expression between at least two strains or species. We identify, on a gene-by-gene basis, the evolutionary forces that shape this variation and show that, both within the transcriptional network that controls metamorphosis and across the whole genome, the expression changes of transcription factor genes are relatively stable, whereas those of their downstream targets are more likely to have evolved. Our results demonstrate extensive evolution of developmental gene expression among closely related species.This publication has 42 references indexed in Scilit:
- DEVELOPMENTALGENOMICAPPROACHES INMODELORGANISMSAnnual Review of Genomics and Human Genetics, 2002
- Identification of genes involved in Drosophila melanogaster geotaxis, a complex behavioral traitNature Genetics, 2002
- Comparison of Methods for Image Analysis on cDNA Microarray DataJournal of Computational and Graphical Statistics, 2002
- Functional genomics and the study of development, variation and evolutionNature Reviews Genetics, 2001
- Analysis of Variance for Gene Expression Microarray DataJournal of Computational Biology, 2000
- Microarray Analysis of Drosophila Development During MetamorphosisScience, 1999
- Homologues, Natural Kinds and the Evolution of ModularityAmerican Zoologist, 1996
- How can a character be developmentally constrained despite variation in developmental pathways?Journal of Evolutionary Biology, 1993
- A system for mapping DNA sequences in the chromosomes of Drosophila melanogasterCell, 1974
- The metamorphosis of Drosophila melanogaster, including an accurately timed account of the principal morphological changesJournal of Morphology, 1936