Comparison of maximal gastric secretion in smokers and non-smokers with and without duodenal ulcer.
Open Access
- 1 May 1987
- Vol. 28 (5), 557-560
- https://doi.org/10.1136/gut.28.5.557
Abstract
Maximal gastric secretion was induced in 122 control subjects (without peptic ulcer) and 201 preoperative duodenal ulcer patients by intravenous histamine acid phosphate (130 nmol/kg/h), and measured as Vg (ml/h) and MAO (mmol/h). In both groups, men secreted more than women, and smokers secreted more than non-smokers. Significant correlations were found between maximal gastric secretion on the one hand, and height, age, and chronic smoking on the other. After standardisation for these factors, including standardisation to zero smoking, the subgroups of the controls no longer differed significantly, as was also the case for the duodenal ulcer patients. Thus, differences in height, age, and smoking habit were sufficient to account for the variation in maximal secretion between individuals in either the control or duodenal ulcer groups. Even after standardisation, however, the duodenal ulcer patients still secreted significantly more than the controls, and therefore, although chronic smoking has been shown to affect maximal gastric secretion, it does not appear to be the sole reason for hypersecretion in duodenal ulcer patients.Keywords
This publication has 6 references indexed in Scilit:
- Maximal gastric secretion in smokers and non-smokers with duodenal ulcerBritish Journal of Surgery, 1985
- Cigarette smoking, gastric acid secretion, and serum pepsinogen I concentrations in duodenal ulcer patients.Gut, 1985
- Smoking, Alcohol, Coffee, and Familial Factors: Any Associations with Peptic Ulcer Disease?: A Clinically and Radiologically Prospective StudyScandinavian Journal of Gastroenterology, 1985
- A standardized technique for the performance of accurate gastric secretion studiesInflammation Research, 1979
- The Accurate assessment of maximal gastric secretion in control subjects and patients with duodenal ulcerBritish Journal of Surgery, 1971
- Lean body mass, gastric acid, and peptic ulcerGut, 1969