Utilization rates, complications and costs of percutaneous liver biopsy: a population‐based study including 4275 biopsies
- 10 April 2008
- journal article
- Published by Wiley in Liver International
- Vol. 28 (5), 705-712
- https://doi.org/10.1111/j.1478-3231.2008.01691.x
Abstract
Liver biopsy is an important tool in the management of patients with liver disease. Because biopsy practices may be changing, we studied patterns of use in a large Canadian Health Region. We aimed to describe trends in biopsy utilization and the incidence and costs of complications from a population-based perspective. Administrative databases were used to identify percutaneous liver biopsies performed between 1994 and 2002. Significant complications were identified by reviewing medical records of patients hospitalized within 7 days of a biopsy and those with a diagnostic code indicative of a procedural complication. Analyses of biopsy rates employed Poisson regression. Between 1994 and 2002, 3627 patients had 4275 liver biopsies (median 1 per patient; range 1-12). Radiologists performed the majority (90%), particularly during the latter years (1994 vs. 2002: 73 vs. 98%; P<0.0001). The overall annual biopsy rate was 54.8 per 100 000 population with a 41% (95% CI 23-61%) increase between 1994 and 2002. Annual increases were greatest in males and patients 30-59 years. Thirty-two patients (0.75%) had significant biopsy-related complications (1994-1997 vs. 1998-2002: 1.28 vs. 0.44%; P=0.003). Pain requiring admission (0.51%) and bleeding (0.35%) were most common. Six patients (0.14%) died; all had malignancies. The median direct cost of a hospitalization for complications was $4579 (range $1164-29 641). Liver biopsy rates are increasing likely owing to the changing epidemiology and management of common liver diseases. The similarity of the complication rate in our population-based study with estimates from specialized centres supports the safety of this important procedure.Keywords
This publication has 26 references indexed in Scilit:
- The incidence and risks of liver biopsy in non-cirrhotic patients: An evaluation of 3806 biopsiesGut, 2007
- Colonoscopy Demand and Capacity in New HampshireAmerican Journal of Preventive Medicine, 2007
- Twenty‐year audit of percutaneous liver biopsy in a major Australian teaching hospitalInternal Medicine Journal, 2006
- Management of hepatocellular carcinomaHepatology, 2005
- Short Recovery Time After Percutaneous Liver Biopsy: Should We Change Our Current Practices?Clinical Gastroenterology and Hepatology, 2005
- Liver BiopsyJournal of Clinical Gastroenterology, 2005
- Practices of Liver Biopsy in France: Results of a Prospective Nationwide SurveyHepatology, 2000
- The role of ultrasonography and automatic-needle biopsy in outpatient percutaneous liver biopsyHepatology, 1996
- Indications, methods, and outcomes of percutaneous liver biopsy in England and Wales: an audit by the British Society of Gastroenterology and the Royal College of Physicians of London.Gut, 1995
- Complications following percutaneous liver biopsyJournal of Hepatology, 1986