New use of BCG for recombinant vaccines
- 1 June 1991
- journal article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 351 (6326), 456-460
- https://doi.org/10.1038/351456a0
Abstract
BCG, a live attenuated tubercle bacillus, is the most widely used vaccine in the world and is also a useful vaccine vehicle for delivering protective antigens of multiple pathogens. Extrachromosomal and integrative expression vectors carrying the regulatory sequences for major BCG heat-shock proteins have been developed to allow expression of foreign antigens in BCG. These recombinant BCG strains can elicit long-lasting humoral and cellular immune responses to foreign antigens in mice.Keywords
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