Budding and vesiculation induced by conical membrane inclusions
- 3 September 2009
- journal article
- research article
- Published by American Physical Society (APS) in Physical Review E
- Vol. 80 (3), 031901
- https://doi.org/10.1103/physreve.80.031901
Abstract
Conical inclusions in a lipid bilayer generate an overall spontaneous curvature of the membrane that depends on concentration and geometry of the inclusions. Examples are integral and attached membrane proteins, viruses, and lipid domains. We propose an analytical model to study budding and vesiculation of the lipid bilayer membrane, which is based on the membrane bending energy and the translational entropy of the inclusions. If the inclusions are placed on a membrane with similar curvature radius, their repulsive membrane-mediated interaction is screened. Therefore, for high inclusion density the inclusions aggregate, induce bud formation, and finally vesiculation. Already with the bending energy alone our model allows the prediction of bud radii. However, in case the inclusions induce a single large vesicle to split into two smaller vesicles, bending energy alone predicts that the smaller vesicles have different sizes whereas the translational entropy favors the formation of equal-sized vesicles. Our results agree well with those of recent computer simulations.Comment: 11 pages, 12 figureKeywords
This publication has 56 references indexed in Scilit:
- Biophysical approaches to protein-induced membrane deformations in traffickingCurrent Opinion in Cell Biology, 2008
- Protein area occupancy at the center of the red blood cell membraneProceedings of the National Academy of Sciences of the United States of America, 2008
- Bending over to attractNature, 2007
- A general amphipathic α-helical motif for sensing membrane curvatureNature Structural & Molecular Biology, 2007
- Direct observation of Bin/amphiphysin/Rvs (BAR) domain-induced membrane curvature by means of molecular dynamics simulationsProceedings of the National Academy of Sciences of the United States of America, 2006
- Curvature-dependent lateral distribution of raft markers in the human erythrocyte membraneMolecular Membrane Biology, 2006
- Fluctuation spectrum of membranes with anchored linear and star polymersPhysical Review E, 2005
- Scale-dependent rigidity of polymer-ornamented membranesThe European Physical Journal E, 2002
- Curvature of clathrin-coated pits driven by epsinNature, 2002
- Shape Transformations of Domains in Mixed-Fluid Films and Bilayer MembranesEurophysics Letters, 1994