A Prospective Study of Meat and Fat Intake in Relation to Small Intestinal Cancer
- 14 November 2008
- journal article
- Published by American Association for Cancer Research (AACR) in Cancer Research
- Vol. 68 (22), 9274-9279
- https://doi.org/10.1158/0008-5472.can-08-2015
Abstract
Diets high in red and processed meats are associated with carcinogenesis of the large intestine, but no prospective study has examined meat and fat intake in relation to cancer of the small intestine. We prospectively investigated meat and fat intakes, estimated from a food frequency questionnaire, in relation to small intestinal cancer among half a million men and women enrolled in the NIH-AARP Diet and Health Study. We used Cox proportional hazards regression to estimate hazard ratios (HR) and 95% confidence intervals (95% CI). During up to 8 years of follow-up, 60 adenocarcinomas and 80 carcinoid tumors of the small intestine were diagnosed. Despite slightly elevated HRs for red meat, there were no clear associations for red or processed meat intake and either adenocarcinoma or carcinoid tumors of the small intestine. In contrast, we noted a markedly elevated risk for carcinoid tumors of the small intestine with saturated fat intake in both the categorical (highest versus lowest tertile: HR, 3.18; 95% CI, 1.62–6.25) and continuous data (HR, 3.72; 95% CI, 1.79–7.74 for each 10-g increase in intake per 1,000 kcal). Our findings suggest that the positive associations for meat intake reported in previous case-control studies may partly be explained by saturated fat intake.[Cancer Res 2008;68(22):9274–9]Keywords
This publication has 34 references indexed in Scilit:
- Performance of a food-frequency questionnaire in the US NIH–AARP (National Institutes of Health–American Association of Retired Persons) Diet and Health StudyPublic Health Nutrition, 2008
- A Prospective Study of Red and Processed Meat Intake in Relation to Cancer RiskPLoS Medicine, 2007
- Meat consumption and risk of colorectal cancer: A meta‐analysis of prospective studiesInternational Journal of Cancer, 2006
- Meat Intake and Risk of Stomach and Esophageal Adenocarcinoma Within the European Prospective Investigation Into Cancer and Nutrition (EPIC)JNCI Journal of the National Cancer Institute, 2006
- Associations between small intestine cancer and other primary cancers: An international population‐based studyInternational Journal of Cancer, 2005
- Dietary Benzo[a]Pyrene Intake and Risk of Colorectal AdenomaCancer Epidemiology, Biomarkers & Prevention, 2005
- Dietary exposure and urinary excretion of total N‐nitroso compounds, nitrosamino acids and volatile nitrosamine in inhabitants of high‐ and low‐risk areas for esophageal cancer in southern ChinaInternational Journal of Cancer, 2002
- Design and Serendipity in Establishing a Large Cohort with Wide Dietary Intake DistributionsAmerican Journal of Epidemiology, 2001
- Types of dietary fat and the incidence of cancer at five sitesPreventive Medicine, 1990
- The problem of profound mismeasurement and the power of epidemiological studies of diet and cancerNutrition and Cancer, 1988