Hypertrophic Scars and Keloids
- 1 January 2003
- journal article
- review article
- Published by Springer Science and Business Media LLC in American Journal of Clinical Dermatology
- Vol. 4 (4), 235-243
- https://doi.org/10.2165/00128071-200304040-00003
Abstract
Keloid and hypertrophic scars have affected patients and frustrated physicians for centuries. Keloid and hypertrophic scars result from excessive collagen deposition, the cause of which remains elusive. Clinically, these scars can be disfiguring functionally, aesthetically, or both. A thorough understanding of the pathophysiology and clinical nature of the scar can help define the most appropriate treatment strategy. Although many articles have been published on the management of hypertrophic and keloid scars, there is no universally accepted treatment protocol. Prevention of keloid and hypertrophic scars remains the best strategy; therefore, those patients with a predisposition to develop excessive scar formation should avoid nonessential surgery. Once a scar is present, there are many treatments from which to choose. Hypertrophic scars and keloids have been shown to respond to radiation, pressure therapy, cryotherapy, intralesional injections of corticosteroid, interferon and fluorouracil, topical silicone or other dressings, and pulsed-dye laser treatment. Simple surgical excision is usually followed by recurrence unless adjunct therapies are employed. Biologic agents that are directed towards the aberrant collagen proliferation that characterizes keloid and hypertrophic scars might be an important addition to the current armamentarium of modalities in the near future.Keywords
This publication has 100 references indexed in Scilit:
- Are keloids really “gli-loids”?: High-level expression of gli-1 oncogene in keloidsJournal of the American Academy of Dermatology, 2001
- Mathematical Modelling of Nitric Oxide Activity in Wound Healing can explain Keloid and Hypertrophic ScarringJournal of Theoretical Biology, 2000
- KELOIDS: TIME TO DISPEL THE MYTHS?Plastic and Reconstructive Surgery, 1999
- Carbon dioxide laser ablation associated with interferon alfa-2binjections reduces the recurrence of keloidsJournal of the American Academy of Dermatology, 1998
- Improvement of facial acne scars by the 585 nm flashlamp-pumped pulsed dye laserJournal of the American Academy of Dermatology, 1996
- Hyaluronic acid metabolism in keloid fibroblastsJournal of Pediatric Surgery, 1995
- The HLA-DRβ16 allogenotype constitutes a risk factor for hypertrophic scarringHuman Immunology, 1990
- Experience with the Nd:YAG Laser in the Treatment of Keloid ScarsAnnals of Plastic Surgery, 1988
- Silicone gel: a new treatment for burn scars and contracturesBurns, 1983
- THE USE OF A MOLDER SPLINT TO PREVENT CONTRACTURE AFTER SPLIT SKIN GRAFTING ON THE NECKPlastic and Reconstructive Surgery, 1961