The Incidence of Aminoglycoside Antibiotic-Induced Hearing Loss
- 1 April 1990
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA Otolaryngology–Head & Neck Surgery
- Vol. 116 (4), 406-410
- https://doi.org/10.1001/archotol.1990.01870040028008
Abstract
• The definition of ototoxicity in most clinical studies of aminoglycoside antibiotics is an increase in pure-tone threshold from a baseline audiogram ≥ 15 dB at two or more frequencies, or ≥20 dB at one or more frequencies. In this study, test-retest auditory threshold differences of this magnitude were found in a group of 20 normal volunteers who were not taking any known ototoxic drugs. Depending on which of the two criteria for ototoxicity are used, these data represent a 20% or 33% incidence of ototoxicity. We believe that many of the audiometric changes reported to represent aminoglycoside antibiotic ototoxicity may actually represent the normal test-retest variability of pure-tone audiometry. If this is true, the reported incidence of hearing loss due to aminoglycoside antibiotics may be exaggerated. (Arch Otolaryngol Head Neck Surg. 1990;116:406-410)Keywords
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