Cytokinesis, ploidy and aneuploidy
- 14 November 2011
- journal article
- review article
- Published by Wiley in The Journal of Pathology
- Vol. 226 (2), 338-351
- https://doi.org/10.1002/path.3013
Abstract
Cytokinesis is the last step of cell division that physically separates the daughter cells. As such, it ensures the proper inheritance of both nuclear and cytoplasmic contents. Accomplishment of cytokinesis in eukaryotes is dictated by several key events: establishment of the division plane, furrow ingression through contraction of an actomyosin ring and abscission via membrane fusion. Most mammalian somatic cells are diploid. Polyploidy can result from cytokinesis failure and may contribute to the development of pathologies such as cancer. However, polyploidy is essential for cellular differentiation and function in some contexts (eg hepatocytes, megakaryocytes and others). Consequently, the degree of ploidy and the achievement of cytokinesis must be tightly regulated throughout an organism and among different cell types. In this review we will highlight several examples of normal and pathological polyploidy, focusing on those caused by a controlled failure or dysregulation of cytokinesis, respectively. Last, we propose therapeutic routes to control cytokinesis to restore or block cell division. Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.Keywords
This publication has 104 references indexed in Scilit:
- Formation of mammalian erythrocytes: chromatin condensation and enucleationTrends in Cell Biology, 2011
- A non-genetic route to aneuploidy in human cancersNature, 2011
- A Secreted Protein Promotes Cleavage Furrow Maturation during CytokinesisCurrent Biology, 2011
- The ploidy conveyor of mature hepatocytes as a source of genetic variationNature, 2010
- A mechanism linking extra centrosomes to chromosomal instabilityNature, 2009
- Structural basis for midbody targeting of spastin by the ESCRT-III protein CHMP1BNature Structural & Molecular Biology, 2008
- Cytokinesis of neuroepithelial cells can divide their basal process before anaphaseThe EMBO Journal, 2008
- ESCRT complexes and the biogenesis of multivesicular bodiesCurrent Opinion in Cell Biology, 2008
- Conversion of midbodies into germ cell intercellular bridgesDevelopmental Biology, 2007
- Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitiveNature, 2004