Oral microbial biofilms and plaque-related diseases: microbial communities and their role in the shift from oral health to disease
- 1 December 2003
- journal article
- review article
- Published by Springer Science and Business Media LLC in Clinical Oral Investigations
- Vol. 7 (4), 181-188
- https://doi.org/10.1007/s00784-003-0236-1
Abstract
Many oral pathologies, such as dental caries, periodontal disease and peri-implantitis are plaque-related. Dental plaque is a microbial biofilm formed by organisms tightly bound to a solid substrate and each other by means of an exopolymer matrix. Bacteria exhibit difefrent properties when contained within a biofilm. Knowing the mechanism controlling the formation and deveopment of biofilms can help to understand the emergence and progression of such pathologies and to plan effective treatment. Most periodontal pathogens are common saprophytes of the oral cavity, expressing their virulence only in a sisceptible host or when some changes comw about in the oral envirnment. Physical, metabolic and physiological interactions may cause positive or negative effects among the various microbiota present.Such mechanisms of antagonisms/synergy select the bacterial population and alterations of its composition affect the balance with the host and may lead to pathology. The efefctivenes of antimicrobial agents, as measured trough in vitro tests, is dramatically reduced in vivo due to the properties of the microbial community: mature, intact biofilms are les sensitive to such agents, as the exopolymer matrix, bacterial enzymes and slow growth rate hinder the action of chemotherapeutic agents. The present literature review aims to examine the most representative sudies, focusing on the characteristics of the bacterial communities and the crucial shift from the oral health to plaque-related diseases.ud Keywords: Microbial film - Dental plaque - Periodontal disease - Peri-implantitis - Bacterial virulence - Host susceptibilitKeywords
This publication has 69 references indexed in Scilit:
- Generalized Juvenile Periodontitis: Report of a Familial Case Followed for 5 YearsThe Journal of Periodontology, 1990
- Difficulties encountered in the search for the etiologic agents of destructive periodontal diseasesJournal of Clinical Periodontology, 1987
- Diagnosis of periodontal disease using rapid identification of “activity‐related” gram‐negative speciesJournal of Periodontal Research, 1987
- Natural history of periodontal disease in manJournal of Clinical Periodontology, 1986
- New concepts of destructive periodontal diseaseJournal of Clinical Periodontology, 1984
- Microbiota of gingivitis in manEuropean Journal of Oral Sciences, 1978
- Microbiology of Periodontal Disease—Present Status and Future ConsiderationsThe Journal of Periodontology, 1977
- Microflora in the healthy gingival sulcus in manEuropean Journal of Oral Sciences, 1977
- Structure of the Microbial Flora Associated with Periodontal Health and Disease in Man: A Light and Electron Microscopic StudyThe Journal of Periodontology, 1976
- Experimental Gingivitis in ManThe Journal of Periodontology, 1965