Adaptive and Mutational Resistance: Role of Porins and Efflux Pumps in Drug Resistance
Top Cited Papers
- 1 October 2012
- journal article
- review article
- Published by American Society for Microbiology in Clinical Microbiology Reviews
- Vol. 25 (4), 661-681
- https://doi.org/10.1128/cmr.00043-12
Abstract
SUMMARY The substantial use of antibiotics in the clinic, combined with a dearth of new antibiotic classes, has led to a gradual increase in the resistance of bacterial pathogens to these compounds. Among the various mechanisms by which bacteria endure the action of antibiotics, those affecting influx and efflux are of particular importance, as they limit the interaction of the drug with its intracellular targets and, consequently, its deleterious effects on the cell. This review evaluates the impact of porins and efflux pumps on two major types of resistance, namely, mutational and adaptive types of resistance, both of which are regarded as key phenomena in the global rise of antibiotic resistance among pathogenic microorganisms. In particular, we explain how adaptive and mutational events can dramatically influence the outcome of antibiotic therapy by altering the mechanisms of influx and efflux of antibiotics. The identification of porins and pumps as major resistance markers has opened new possibilities for the development of novel therapeutic strategies directed specifically against these mechanisms.Keywords
This publication has 162 references indexed in Scilit:
- EmmdR, a new member of the MATE family of multidrug transporters, extrudes quinolones from Enterobacter cloacaeArchiv für Mikrobiologie, 2011
- Activity of the efflux pump inhibitor phenylalanine-arginine β-naphthylamide against the AdeFGH pump of Acinetobacter baumanniiInternational Journal of Antimicrobial Agents, 2011
- Down-regulation of porin M35 in Moraxella catarrhalis by aminopenicillins and environmental factors and its potential contribution to the mechanism of resistance to aminopenicillinsJournal of Antimicrobial Chemotherapy, 2010
- Contribution of OmpK36 to carbapenem susceptibility in KPC-producing Klebsiella pneumoniaeJournal of Medical Microbiology, 2009
- AcrAB Multidrug Efflux Pump Regulation in Salmonella enterica serovar Typhimurium by RamA in Response to Environmental SignalsJournal of Biological Chemistry, 2008
- Variation of the mexT gene, a regulator of the MexEF-OprN efflux pump expression in wild-type strains of Pseudomonas aeruginosaFEMS Microbiology Letters, 2000
- Microbial genome analyses: global comparisons of transport capabilities based on phylogenies, bioenergetics and substrate specificities 1 1Edited by G. Von HeijneJournal of Molecular Biology, 1998
- The ompB locus and the regulation of the major outer membrane porin proteins of Escherichia coli K12Journal of Molecular Biology, 1981
- Plasmid-mediated tetracycline resistance in escherichia coli involves increased efflux of the antibioticBiochemical and Biophysical Research Communications, 1980
- Plasmid-determined tetracycline resistance involves new transport systems for tetracyclineNature, 1978