GITR: A Modulator of Immune Response and Inflammation
- 1 January 2009
- book chapter
- review article
- Published by Springer Science and Business Media LLC in Advances in Experimental Medicine and Biology
- Vol. 647, 156-173
- https://doi.org/10.1007/978-0-387-89520-8_11
Abstract
Glucocorticoid-Induced TNFR-Related (GITR) protein belongs to Tumor Necrosis Factor Receptor Superfamily (TNFRSF) and stimulates both the acquired and innate immunity. It is expressed in several cells and tissues, including T and Natural Killer (NK) cells and is activated by its ligand, GITRL, mainly expressed on Antigen Presenting Cells (APCs) and endothelial cells. GITR/GITRL system participates in the development of autoimmune/inflammatory responses and graft vs. host disease and potentiates response to infection and tumors. These effects are due to several concurrent mechanisms including: co-activation of effector T-cells, inhibition of regulatory T (Treg) cells, NK-cell co-activation, activation of macrophages, modulation of DC function and regulation of the extravasation process. In this chapter we describe: 1) the main structural features of GITR and GITRL, 2) the transduction pathways activated by GITR triggering, 3) the effects derived from GITR/GITRL system interaction, considering the interplay between the different cells of the immune system. Moreover, the potential use of GITR/GITRL modulators in disease treatment is discussed.This publication has 80 references indexed in Scilit:
- GITR modulates innate and adaptive mucosal immunity during the development of experimental colitis in miceGut, 2007
- Glucocorticoid-induced tumour necrosis factor receptor family-related receptor signalling exacerbates hapten-induced colitis by CD4+T cellsImmunology, 2006
- Glucocorticoid‐induced tumour necrosis factor receptor family related protein (GITR) mediates inflammatory activation of macrophages that can destabilize atherosclerotic plaquesImmunology, 2006
- Agonist Anti-GITR Antibody Enhances Vaccine-Induced CD8+ T-Cell Responses and Tumor ImmunityCancer Research, 2006
- Protein Methyltransferase 2 Inhibits NF-κB Function and Promotes ApoptosisMolecular and Cellular Biology, 2006
- Human plasmacytoid predendritic cells activate NK cells through glucocorticoid-induced tumor necrosis factor receptor-ligand (GITRL)Blood, 2006
- In Vivo Kinetics of GITR and GITR Ligand Expression and Their Functional Significance in Regulating Viral ImmunopathologyJournal of Virology, 2005
- The soluble glucocorticoid-induced tumor necrosis factor receptor causes cell cycle arrest and apoptosis in murine macrophagesBiochemical and Biophysical Research Communications, 2004
- Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITRCurrent Biology, 1999
- The Mammalian Immediate-early TIS21 Protein and the Leukemia-associated BTG1 Protein Interact with a Protein-arginine -MethyltransferaseOnline Journal of Public Health Informatics, 1996