Capping and in vivo toxicity studies of gold nanoparticles
Open Access
- 9 February 2012
- journal article
- Published by IOP Publishing in Advances in Natural Sciences: Nanoscience and Nanotechnology
Abstract
Water-dispersed colloidal gold nanoparticles (AuNPs) with high concentration were synthesized from metal precursor HAuCl 4. The bovine serum albumin (BSA) and heterobiofunctionalized thiol polyethylene glycol acid (HS–PEG–COOH) were used as biofunctionalized layers for the synthesized AuNPs. The BSA and HS–PEG–COOH bound to the AuNPs were characterized qualitatively and quantitatively by transmission electron microscope and UV-VS spectrophotometer. The fabricated BSA and HS–PEG–COOH-capped AuNPs were introduced in mouse to study its toxicity and its availability in the liver.Keywords
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