High precision biometry of pseudophakic eyes using partial coherence interferometry

Abstract

To investigate the applicability of the scanning version of dual-beam partial coherence interferometry (PCI) for measuring the anterior segment and axial length of pseudophakic eyes in a clinical setting and to determine the achievable precision with this biometry technique. Department of Ophthalmology, Vienna General Hospital, and Institute of Medical Physics, University of Vienna, Austria. Partial coherence interferometry was performed in 39 pseudophakic eyes of 39 patients after implantation of a foldable acrylic intraocular lens (IOL). Effective lens position (ELP), IOL thickness and lens-capsule distance (LCD) were determined with a precision of 2 to 3 microns; corneal thickness and axial eye length, with a precision of 0.8 and 5.0 microns, respectively. The mean ELP of the IOL was 4.093 mm +/- 0.290 (SD). In 7 eyes (18%), a positive LCD of 68 +/- 40 microns was detected with PCI. Mean corneal thickness was 526.4 +/- 31.5 microns; mean IOL thickness, 791.5 +/- 40.2 microns; and mean axial length, 23.388 +/- 0.824 mm. The scanning version of PCI enables high precision (< or = 5 microns) and high resolution (approximately 12 microns) biometry of pseudophakic eyes that is better than conventional ultrasound by a factor of more than 20. For the first time, positive LCD, a possible risk factor for posterior capsule opacification, could be detected and quantified. Furthermore, this technique offers a high degree of comfort for the patient since it is a noncontact method with no need for local anesthesia or pupil dilation and has a reduced risk of corneal infection.