Break‐up of Two‐Dimensional MnO2 Nanosheets Promotes Ultrasensitive pH‐Triggered Theranostics of Cancer
Top Cited Papers
- 22 August 2014
- journal article
- research article
- Published by Wiley in Advanced Materials
- Vol. 26 (41), 7019-7026
- https://doi.org/10.1002/adma.201402572
Abstract
Chemically exfoliated two‐dimensional MnO2 nanosheets are successfully modified with amino‐polyethylene glycol as a theranostic platform for ultrasensitive stimuli‐responsive theranostics of cancer. The highly dispersed MnO2 nanosheets exhibit a unique break‐up in the mildly acidic microenvironment of tumor tissues, which could substantially enhance their in vitro and in vivo performances in T1‐weighted magnetic resonance imaging. Such a pH‐triggered breaking‐up behavior could further promote the fast release of loaded anticancer drugs for concurrent pH‐responsive drug release and circumvent the multidrug resistance of cancer cells.Keywords
Funding Information
- Australian Research Council
- National Nature Science Foundation of China (51302293, 51132009)
- Foundation for Youth Scholar of State Key Laboratory of High Performance Ceramics and Superfine Microstructure (SKL201203)
This publication has 52 references indexed in Scilit:
- Multimodal Imaging Guided Photothermal Therapy using Functionalized Graphene Nanosheets Anchored with Magnetic NanoparticlesAdvanced Materials, 2012
- Manganese-based MRI contrast agents: past, present, and futureTetrahedron, 2011
- pH-Titratable Superparamagnetic Iron Oxide for Improved Nanoparticle Accumulation in Acidic Tumor MicroenvironmentsACS Nano, 2011
- Responsive Theranostic Systems: Integration of Diagnostic Imaging Agents and Responsive Controlled Release Drug Delivery CarriersAccounts of Chemical Research, 2011
- Biocompatible and pH-Sensitive PLGA Encapsulated MnO Nanocrystals for Molecular and Cellular MRIACS Nano, 2011
- Mesoporous Silica-Coated Hollow Manganese Oxide Nanoparticles as Positive T1 Contrast Agents for Labeling and MRI Tracking of Adipose-Derived Mesenchymal Stem CellsJournal of the American Chemical Society, 2011
- Revisiting an old friend: manganese‐based MRI contrast agentsWIREs Nanomedicine and Nanobiotechnology, 2010
- Alternatives to Gadolinium-Based Metal Chelates for Magnetic Resonance ImagingChemical Reviews, 2010
- Nephrogenic Systemic Fibrosis: Incidence, Associations, and Effect of Risk Factor Assessment—Report of 33 CasesRadiology, 2009
- Recent progress in tumor pH targeting nanotechnologyJournal of Controlled Release, 2008