Hepatitis B Surface Antigen Could Contribute to the Immunopathogenesis of Hepatitis B Virus Infection
Open Access
- 16 January 2013
- journal article
- review article
- Published by Hindawi Limited in ISRN Gastroenterology
- Vol. 2013, 1-8
- https://doi.org/10.1155/2013/935295
Abstract
Various findings concerning the clinical significance of quantitative changes in hepatitis B surface antigen (HBsAg) during the acute and chronic phase of hepatitis B virus (HBV) infection have been reported. In addition to being a biomarker of HBV-replication activity, it has been reported that HBsAg could contribute to the immunopathogenesis of HBV persistent infection. Moreover, HBsAg could become an attractive target for immune therapy, since the cellular and humeral immune response against HBsAg might be able to control the HBV replication and life cycle. However, several reports have described the immune suppressive function of HBsAg. HBsAg might suppress monocytes, dendritic cells (DCs), natural killer (NK), and natural killer T (NK-T) cells by direct interaction. On the other hand, cytotoxic T lymphocytes (CTLs) and helper T (Th) cells were exhausted by high amounts of HBsAg. In this paper, we focused on the immunological aspects of HBsAg, since better understanding of the interaction between HBsAg and immune cells could contribute to the development of an immune therapy as well as a biomarker of the state of HBV persistent infection.Keywords
This publication has 98 references indexed in Scilit:
- α-Fetoprotein impairs activation of natural killer cells by inhibiting the function of dendritic cellsClinical and Experimental Immunology, 2011
- Immune and Viral Profile from Tolerance to Hepatitis B Surface Antigen Clearance: a Longitudinal Study of Vertically Hepatitis B Virus-Infected Children on Combined TherapyJournal of Virology, 2011
- Influence of Serum and Soluble CD25 (sCD25) on Regulatory and Effector T‐cell Function in Hepatocellular CarcinomaScandinavian Journal of Immunology, 2010
- Hepatitis B virus surface antigen impairs myeloid dendritic cell function: a possible immune escape mechanism of hepatitis B virusImmunology, 2009
- The influence of hepatitis B virus genotype and subgenotype on the natural history of chronic hepatitis BHepatology International, 2008
- A New Population of Myeloid-Derived Suppressor Cells in Hepatocellular Carcinoma Patients Induces CD4+CD25+Foxp3+ T CellsGastroenterology, 2008
- Peripheral blood dendritic cells are phenotypically and functionally intact in chronic hepatitis B virus (HBV) infectionClinical and Experimental Immunology, 2007
- Chemoimmunotherapy of Chronic Hepatitis B Virus Infection in the Woodchuck Model Overcomes Immunologic Tolerance and Restores T-Cell Responses to Pre-S and S Regions of the Viral Envelope ProteinJournal of Virology, 2007
- Inhibition of Hepatitis B Virus Polymerase by EntecavirJournal of Virology, 2007
- Immunology of hepatitis B virus and hepatitis C virus infectionNature Reviews Immunology, 2005