Ocular Adverse Events After COVID-19 Vaccination
- 24 September 2021
- journal article
- review article
- Published by Taylor & Francis Ltd in Ocular Immunology and Inflammation
- Vol. 29 (6), 1216-1224
- https://doi.org/10.1080/09273948.2021.1976221
Abstract
The COVID-19 pandemic has galvanized the development of new vaccines at an unprecedented pace. Since the widespread implementation of vaccination campaigns, reports of ocular adverse effects after COVID-19 vaccinations have emerged. This review summarizes ocular adverse effects possibly associated with COVID-19 vaccination, and discusses their clinical characteristics and management. Narrative Literature Review. Ocular adverse effects of COVID-19 vaccinations include facial nerve palsy, abducens nerve palsy, acute macular neuroretinopathy, central serous retinopathy, thrombosis, uveitis, multiple evanescent white dot syndrome, Vogt-Koyanagi-Harada disease reactivation, and new-onset Graves’ Disease. Studies in current literature are primarily retrospective case series or isolated case reports – these are inherently weak in establishing association or causality. Nevertheless, the described presentations resemble the reported ocular manifestations of the COVID-19 disease itself. Hence, we hypothesize that the human body’s immune response to COVID-19 vaccinations may be involved in the pathogenesis of the ocular adverse effects post-COVID-19 vaccination. Ophthalmologists and generalists should be aware of the possible, albeit rare, ocular adverse effects after COVID-19 vaccination.Keywords
This publication has 73 references indexed in Scilit:
- Evidence for Seasonal Variation of Bell’s Palsy in GermanyNeuroepidemiology, 2018
- Vogt-Koyanagi-Harada Disease Associated with Hepatitis B VaccinationOcular Immunology and Inflammation, 2018
- Multiple Evanescent White Dot Syndrome Following Intradermal Influenza VaccinationOcular Immunology and Inflammation, 2018
- The Effect of Oral Contraceptive Pills on the Macula, the Retinal Nerve Fiber Layer, and Choroidal ThicknessMedical Science Monitor, 2017
- Type I interferon–mediated monogenic autoinflammation: The type I interferonopathies, a conceptual overviewThe Journal of Experimental Medicine, 2016
- Vaccines and multiple sclerosis: a systematic reviewZeitschrift für Neurologie, 2016
- Acute macular neuroretinopathy: A comprehensive review of the literatureSurvey of Ophthalmology, 2016
- Stromal rejection in a deep anterior lamellar keratoplasty following influenza vaccinationClinical & Experimental Ophthalmology, 2015
- Corneal transplantationThe Lancet, 2012
- Identification of estrogen and progesterone receptor mRNA expression in the conjunctiva of premenopausal women.2002