In VitroSusceptibility of Nondermatophyte Molds Isolated from Onycomycosis to Antifungal Drugs
- 1 August 2009
- journal article
- Published by Taylor & Francis Ltd in Journal of Chemotherapy
- Vol. 21 (4), 403-407
- https://doi.org/10.1179/joc.2009.21.4.403
Abstract
Despite many advances in antifungal drug development and therapy, onychomycosis due to nondermatophyte molds (NDM) remains difficult to treat. Using a reference microdilution method (CLSI M38-A), the antifungal susceptibility to bifonazole, ciclopiroxolamine, fenticonazole, itraconazole, ketoconazole, miconazole, terbinafine and tioconazole of 64 molds isolated from toenail onychomycosis was studied. All the strains showed good susceptibility to ciclopiroxolamine. Aspergillus had excellent susceptibility to itraconazole followed by miconazole, ketoconazole, tioconazole, fenticonazole and terbinafine. The isolated species had variable susceptibility to bifonazole. Scopulariopsis had wide MIC ranges for all antifungal drugs tested except ciclopiroxolamine. Fusarium and Acremonium had reduced susceptibility to antifungal drugs tested. Nevertheless, some strains show low MICs for ketoconazole, miconazole and tioconazole.Studies to evaluate in vitro susceptibility testing using CLSI methods for NDM onychomycosis should be undertaken.Keywords
This publication has 15 references indexed in Scilit:
- OnychomycosisMycoses, 2007
- Study of onychomycosis: Prevailing fungi and pattern of infectionIndian Journal of Medical Microbiology, 2007
- Topical antifungal drugs for the treatment of onychomycosis: an overview of current strategies for monotherapy and combination therapyJournal of the European Academy of Dermatology and Venereology, 2004
- Cumulative meta-analysis of systemic antifungal agents for the treatment of onychomycosisBritish Journal of Dermatology, 2004
- Onicomicoses por fungos emergentes: análise clínica, diagnóstico laboratorial e revisãoAnais Brasileiros de Dermatologia, 2003
- Guidelines for treatment of onychomycosisBritish Journal of Dermatology, 2003
- The role of nondermatophyte molds in onychomycosis: diagnosis and treatmentDermatologic Therapy, 2002
- Onychomycosis caused by nondermatophytic molds: Clinical features and response to treatment of 59 casesJournal of the American Academy of Dermatology, 2000
- Clinical pearl: Diagnostic procedures for tinea capitisJournal of the American Academy of Dermatology, 1996
- Fortnightly Review: Fungal nail disease: a guide to good practice (report of a Working Group of the British Society for Medical Mycology)BMJ, 1995