Attenuation of Insulin-stimulated Insulin Receptor Substrate-1 Serine 307 Phosphorylation in Insulin Resistance of Type 2 Diabetes
Open Access
- 1 October 2005
- journal article
- Published by Elsevier BV
- Vol. 280 (41), 34389-34392
- https://doi.org/10.1074/jbc.c500230200
Abstract
No abstract availableThis publication has 35 references indexed in Scilit:
- Insulin resistance in human adipocytes occurs downstream of IRS1 after surgical cell isolation but at the level of phosphorylation of IRS1 in type 2 diabetesThe FEBS Journal, 2004
- A Novel T608R Missense Mutation in Insulin Receptor Substrate-1 Identified in a Subject with Type 2 Diabetes Impairs Metabolic Insulin SignalingJournal of Clinical Endocrinology & Metabolism, 2003
- Insulin signalling and the regulation of glucose and lipid metabolismNature, 2001
- Turning down insulin signalingJCI Insight, 2001
- The Gly->Arg972 Amino Acid Polymorphism in Insulin Receptor Substrate-1 Affects Glucose Metabolism in Skeletal Muscle CellsJournal of Clinical Endocrinology & Metabolism, 2000
- Characterization of signal transduction and glucose transport in skeletal muscle from type 2 diabetic patients.Diabetes, 2000
- Insulin resistance differentially affects the PI 3-kinase– and MAP kinase–mediated signaling in human muscleJCI Insight, 2000
- Impact of Natural IRS-1 Mutations on Insulin Signals: Mutations of IRS-1 in the PTB Domain and Near SH2 Protein Binding Sites Result in Impaired Function at Different Steps of IRS-1 SignalingDiabetes, 1997
- A common amino acid polymorphism in insulin receptor substrate-1 causes impaired insulin signaling. Evidence from transfection studies.JCI Insight, 1996
- Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects.JCI Insight, 1995