Endogenous Digitalis-like Factor or Factors

Abstract

The roles of the renin–angiotensin–aldosterone and antidiuretic (vasopressin) systems in regulating extracellular fluid volume and arterial pressure have been recognized for many years. More recently, atrial natriuretic factor was discovered and shown to be released in several volume-expanded and hypertensive states. This factor may help to remove excess fluid and dilate blood vessels, thereby acting as an antihypertensive hormone. Still another agent may participate in regulating blood volume and pressure. This agent, which may promote hypertension, is the putative endogenous digitalis-like factor.The high concentration of potassium and the low concentration of sodium in the intracellular fluid relative to the . . .