Running speed and maximal oxygen uptake in rats and mice: practical implications for exercise training
- 1 December 2007
- journal article
- research article
- Published by Oxford University Press (OUP) in European Journal of Preventive Cardiology
- Vol. 14 (6), 753-760
- https://doi.org/10.1097/hjr.0b013e3281eacef1
Abstract
Valid and reliable experimental models are essential to gain insight into the cellular and molecular mechanisms underlying the beneficial effects of exercise in prevention, treatment, and rehabilitation of lifestyle-related diseases. Studies with large changes, low variation, and reproducible training outcome require individualized training intensity, controlled by direct measurements of maximal oxygen uptake or heart rate. As this approach is expensive and time consuming, we discuss whether maximal treadmill running speed in a gradually increasing ramp protocol might be sufficient to control intensity without lossing accuracy. Combined data from six studies of rats and mice from our lab demonstrated a close correlation between running speed and oxygen uptake. This relationship changed towards a steeper linear slope after endurance training, indicating improved work economy, that is, less oxygen was consumed at fixed submaximal running speeds. Maximal oxygen uptake increased 40-70% after high-intensity aerobic interval training in mice and rats. The speed at which oxygen uptake reached a plateau, increased in parallel with the change in maximal oxygen uptake during the training period. Although this suggests that running speed can be used to assess training intensity throughout a training program, the problem is to determine the exact relative intensity related to maximal oxygen uptake from running speed alone. We therefore suggest that directly measured oxygen uptake should be used to assess exercise intensity and optimize endurance training in rats and mice. Running speed may serve as a supplement to ensure this intensity. Eur J Cardiovasc Prev Rehabil14: 753-760 © 2007 The European Society of CardiologyKeywords
This publication has 50 references indexed in Scilit:
- Effects of exercise training on cardiac performance, exercise capacity and quality of life in patients with heart failure: A meta‐analysisEuropean Journal of Heart Failure, 2006
- Cardiorespiratory Fitness Levels Among US Youth 12 to 19 Years of AgeArchives of Pediatrics & Adolescent Medicine, 2006
- Prediction of Long-Term Prognosis in 12 169 Men Referred for Cardiac RehabilitationCirculation, 2002
- Exercise Capacity and Mortality among Men Referred for Exercise TestingThe New England Journal of Medicine, 2002
- Peripheral limitations of maximal aerobic capacity in patients with chronic heart failureJournal of Nuclear Cardiology, 2002
- A theoretical analysis of factors determining V̇O2max at sea level and altitudeRespiration Physiology, 1996
- Determinants of Maximal Oxygen Transport and UtilizationAnnual Review of Physiology, 1996
- Algebraic analysis of the determinants of V̇O2,maxRespiration Physiology, 1993
- Maximal oxygen uptakeMedicine & Science in Sports & Exercise, 1992
- Central and Peripheral Aspects of Oxygen Transport and Adaptations with ExerciseSports Medicine, 1991