Metastasis: new perspectives on an old problem
Open Access
- 1 January 2011
- journal article
- review article
- Published by Springer Science and Business Media LLC in Molecular Cancer
- Vol. 10 (1), 22
- https://doi.org/10.1186/1476-4598-10-22
Abstract
Many hypotheses have been postulated to explain the intricate nature of the metastatic process, but none of them completely accounted for the actual biological and clinical observations. Consequently, metastasis still remains an open issue with only few metastasis-inducing proteins experimentally validated so far. Recently proposed novel metastatic model, where serial and parallel metastatic processes are adequately integrated, might help to bridge the current gap between experimental results and clinical observations. In addition, the identification, isolation and molecular characterization of cancer stem cells, a population of the cells within the tumour mass able to proliferate, self-renew and induce tumorigenesis, will shed new light on the complex molecular events mediating metastasis, invasion and resistance to therapy. Understanding the molecular basis of these tumour characteristics will usher in a new age of individualized cancer therapy. In this review article, we will provide a current overview of molecular mechanisms underpinning metastasis, and discuss recent findings in this field obtained by global molecular profiling strategies such as proteomics.Keywords
This publication has 102 references indexed in Scilit:
- Quantitative Proteomic Profiling Studies of Pancreatic Cancer Stem CellsJournal of Proteome Research, 2010
- Identification of Cell Surface Glycoprotein Markers for Glioblastoma-Derived Stem-Like Cells Using a Lectin Microarray and LC−MS/MS ApproachJournal of Proteome Research, 2010
- Latent Bone Metastasis in Breast Cancer Tied to Src-Dependent Survival SignalsCancer Cell, 2009
- Activity-Based Protein Profiling of Protein Tyrosine PhosphatasesPublished by Springer Science and Business Media LLC ,2009
- The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem CellsCell, 2008
- Application of activity-based probes to the study of enzymes involved in cancer progressionCurrent Opinion in Genetics & Development, 2008
- Systemic Spread Is an Early Step in Breast CancerCancer Cell, 2008
- Metastasis genes: A progression puzzleNature, 2002
- Gene expression profiling predicts clinical outcome of breast cancerNature, 2002
- Distinct types of diffuse large B-cell lymphoma identified by gene expression profilingNature, 2000