Statin Use and the Risk of 10 Cancers
- 1 March 2007
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Epidemiology
- Vol. 18 (2), 213-219
- https://doi.org/10.1097/01.ede.0000254694.03027.a1
Abstract
Statins affect the proliferation, survival, and migration of cancer cells, and it is thought that they may have chemopreventive properties in humans. The purpose of the present study was to evaluate the association between statin use and various types of cancer in our hospital-based case–control surveillance study. Data were collected from patients ages 40–79 years who were admitted to participating hospitals in 3 centers in Philadelphia, New York, and Baltimore from 1991 to 2005. Nurses administered questionnaires to obtain information on medication use and other factors. We compared patients who had any of 10 types of cancer (a total of 4913 patients) with controls admitted for noncancer diagnoses (3900 patients). The following cancers were examined individually: female breast (n = 1185), prostate (n = 1226), colorectal (n = 734), lung (n = 464), bladder (n = 240), leukemia (n = 254), pancreas (n = 220), kidney (n = 226), endometrial (n = 220), and non-Hodgkin lymphoma (n = 144). Logistic regression models were used to estimate odds ratios and 95% confidence intervals among regular statin users compared with never-users. Odds ratios were compatible with 1.0 for all cancer types. For the 4 largest cancer sites (breast, prostate, colorectum, and lung), odds ratios did not vary significantly by duration of statin use. Statins are among the most commonly used medications, and durations of use are increasing. The present data do not support either positive or negative associations between statin use and the occurrence of 10 cancer types. Cancer incidence should continue to be monitored among statin users.This publication has 31 references indexed in Scilit:
- Statins and the Risk of Colorectal CancerThe New England Journal of Medicine, 2005
- Why a statin and/or another proven heart healthy agent should be utilized in the next major cancer chemoprevention trial: Part IIUrologic Oncology, 2004
- Potential Anticancer Effects of Statins: Fact or Fiction?Endothelium, 2003
- Chemoprevention of colorectal cancer: problems, progress, and prospectsGastroenterology Clinics of North America, 2002
- HMG-CoA reductase inhibitors and the malignant cell: the statin family of drugs as triggers of tumor-specific apoptosisLeukemia, 2002
- Association of low plasma cholesterol with mortality for cancer at various sites in men: 17-y follow-up of the prospective Basel studyThe American Journal of Clinical Nutrition, 2000
- Mevalonic Acid Is Limiting for N-Linked Glycosylation and Translocation of the Insulin-like Growth Factor-1 Receptor to the Cell SurfacePublished by Elsevier BV ,1996
- Low Serum Cholesterol and MortalityCirculation, 1995
- Low serum cholesterol and the risk of cancer: an analysis of the published prospective studiesCancer Causes & Control, 1991
- Serum cholesterol and risk of cancer in a cohort of 39,000 men and womenJournal of Clinical Epidemiology, 1988