Independent neural coding of reward and movement by pedunculopontine tegmental nucleus neurons in freely navigating rats
- 14 March 2011
- journal article
- Published by Wiley in European Journal of Neuroscience
- Vol. 33 (10), 1885-1896
- https://doi.org/10.1111/j.1460-9568.2011.07649.x
Abstract
Phasic firing of dopamine (DA) neurons in the ventral tegmental area (VTA) and substantia nigra (SN) is likely to be crucial for reward processing that guides learning. One of the key structures implicated in the regulation of this DA burst firing is the pedunculopontine tegmental nucleus (PPTg), which projects to both the VTA and SN. Different literatures suggest that the PPTg serves as a sensory‐gating area for DA cells or it regulates voluntary movement. This study recorded PPTg single‐unit activity as rats perform a spatial navigation task to examine the potential for both reward and movement contributions. PPTg cells showed significant changes in firing relative to reward acquisition, the velocity of movement across the maze and turning behaviors of the rats. Reward, but not movement, correlates were impacted by changes in context, and neither correlate type was affected by reward manipulations (e.g. changing the expected location of a reward). This suggests that the PPTg conjunctively codes both reward and behavioral information, and that the reward information is processed in a context‐dependent manner. The distinct anatomical distribution of reward and movement cells emphasizes different models of synaptic control by PPTg of DA burst firing in the VTA and SN. Relevant to both VTA and SN learning systems, however, PPTg appears to serve as a sensory gating mechanism to facilitate reinforcement learning, while at the same time provides reinforcement‐based guidance of ongoing goal‐directed behaviors.Keywords
This publication has 52 references indexed in Scilit:
- Ventral tegmental area disruption selectively affects CA1/CA2 but not CA3 place fields during a differential reward working memory taskHippocampus, 2011
- Conjunctive encoding of movement and reward by ventral tegmental area neurons in the freely navigating rodent.Behavioral Neuroscience, 2010
- Bar pressing for food: differential consequences of lesions to the anterior versus posterior pedunculopontineEuropean Journal of Neuroscience, 2009
- Disruption of NMDAR-dependent burst firing by dopamine neurons provides selective assessment of phasic dopamine-dependent behaviorProceedings of the National Academy of Sciences, 2009
- Basal ganglia contributions to adaptive navigationBehavioural Brain Research, 2009
- The cholinergic mesopontine tegmentum is a relatively neglected nicotinic master modulator of the dopaminergic system: relevance to drugs of abuse and pathologyBritish Journal of Pharmacology, 2008
- A functional dissociation of the anterior and posterior pedunculopontine tegmental nucleus: excitotoxic lesions have differential effects on locomotion and the response to nicotineBrain Structure and Function, 2008
- Learning-Related Development of Context-Specific Neuronal Responses to Places and Events: The Hippocampal Role in Context ProcessingJournal of Neuroscience, 2006
- Lesions of the dorsomedial nucleus of the thalamus, medial prefrontal cortex and pedunculopontine nucleus: effects on locomotor activity mediated by nucleus accumbens-ventral pallidal circuitryBrain Research, 1987
- Further evidence for segregated output channels from superior colliculus in rat: ipsilateral tecto-pontine and tecto-cuneiform projections have different cells of originBrain Research, 1987