Primary structure of rat chromogranin A and distribution of its mRNA
- 25 January 1988
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 227 (2), 115-121
- https://doi.org/10.1016/0014-5793(88)80880-9
Abstract
The primary structure of rat chromogranin A has been deduced from a rat adrenal cDNA clone. A comparison of rat and bovine chromogranin A reveals several similar features: clusters of polyglutamic acid, similar amino acid composition, position of seven of 10 pairs of basic amino acids, identical placement of the only two cysteine residues, a highly conserved N‐ and C‐terminus, and a sequence homologous to porcine pancreastatin 1–49 [(1986) Nature 324, 476–478]. Unique features of rat chromogranin A are an eicosaglutamine sequence and two potential N‐linked glycosylation sites. Chromogranin A mRNA is detectable in adrenal medulla, anterior pituitary, cerebral cortex, and hippocampus, as well as tumor cell lines derived from pancreas, pituitary, and adrenal medulla.Keywords
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