Nighttime Blood Pressure and White Matter Hyperintensities in Patients With Parkinson Disease
- 6 June 2013
- journal article
- research article
- Published by Taylor & Francis Ltd in Chronobiology International
- Vol. 30 (6), 811-817
- https://doi.org/10.3109/07420528.2013.766618
Abstract
Increasing evidence indicates that nocturnal blood pressure level and/or loss of nocturnal blood pressure dips are sensitive markers of cardiovascular morbidity and mortality. Several studies have suggested that blunted heart rate variability and nocturnal decline in heart rate are also associated with target organ damage. These phenomena occur relatively commonly in patients with Parkinson disease (PD); however, few studies have assessed the consequences of these abnormalities in patients with PD. We investigated the influence of circadian changes in blood pressure and heart rate on white matter hyperintensities (WMHs) in patients with PD. The presence of nocturnal hypertension was associated with increased WMH score, and nighttime systolic pressure was closely related with white matter changes. Blunted heart rate variability and nocturnal decline in heart rate were also related to increasing WMH scores. The non-dipping phenomenon did not influence WMHs. These findings suggest that white matter changes are related to circadian autonomic dysfunction, particularly nocturnal hypertension in patients with PD. Therefore, it is important to monitor nocturnal blood pressure status, because modifying these circadian regulatory disturbances can be beneficial to protect against vascular brain damage in patients with PD. (Author correspondence: neuronet@catholic.ac.kr)Keywords
This publication has 31 references indexed in Scilit:
- Nocturnal Hypertension and Organ Damage in Dippers and NondippersAmerican Journal of Hypertension, 2012
- Central Hemodynamics and Cardiovascular Risk in NondippersThe Journal of Clinical Hypertension, 2011
- The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysisBMJ, 2010
- Progression of Cerebral Atrophy and White Matter Hyperintensities in Patients With Type 2 DiabetesDiabetes Care, 2010
- Cardiac Autonomic Dysfunction Is Associated With White Matter Lesions in Patients With Mild Cognitive ImpairmentThe Journals of Gerontology: Series A, 2009
- 24‐Hour Blood Pressure Monitoring in the Evaluation of Supine Hypertension and Orthostatic HypotensionThe Journal of Clinical Hypertension, 2007
- Characteristic findings on 24-h ambulatory blood pressure monitoring in a series of patients with Parkinson's diseaseEuropean Journal of Internal Medicine, 2006
- Staging of brain pathology related to sporadic Parkinson’s diseaseNeurobiology of Aging, 2003
- Hypertension and cerebral white matter lesions in a prospective cohort studyBrain, 2002
- The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease.Journal of Neurology, Neurosurgery & Psychiatry, 1988