Biomimetic supported membranes from amphiphilic block copolymers
- 4 November 2009
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Soft Matter
- Vol. 6 (1), 179-186
- https://doi.org/10.1039/b917318h
Abstract
A unique combination of surface chemistry and self-assembly of amphiphilic block copolymers was employed to obtain—for the first time—solid-supported biomimetic polymer bilayers. An organized monolayer from sulfur-functionalized poly(butadiene)-b-poly(ethylene oxide) was covalently attached to ultrasmooth gold upon Langmuir-Blodgett transfer. Hydrophobic interactions, on the other hand, were exploited to attach the second monolayer. As a result, we obtained a homogeneous hydrophilic-hydrophobic-hydrophilic structure, similar to supported lipid bilayers by architecture, stability and fluidity. Our polymer bilayers, however, outperform such lipid membranes with regard to tunability of thickness and stability in gaseous environments. As characterized by surface analysis tools (AFM, SPR), solid-supported polymer membranes are smooth with a thickness of ca. 11 nm, resistant to rinsing with aqueous solutions and stable upon drying and rehydration. These properties could be attractive for nanotechnological applications, such as immobilization of functional molecules or nanoparticles, sensor development or preparation of chemically responsive functional surfaces.Keywords
This publication has 48 references indexed in Scilit:
- Fluidic and Air-Stable Supported Lipid Bilayer and Cell-Mimicking MicroarraysJournal of the American Chemical Society, 2008
- The α,α-(1→1) Linkage of Trehalose Is Key to Anhydrobiotic PreservationJournal of the American Chemical Society, 2007
- Interactions of Membrane-Active Peptides with Thick, Neutral, Nonzwitterionic BilayersThe Journal of Physical Chemistry B, 2005
- Self-Assembled Monolayers of Thiolates on Metals as a Form of NanotechnologyChemical Reviews, 2005
- Cryogenic Transmission Electron Microscopy (Cryo-TEM) of Micelles and Vesicles Formed in Water by Poly(ethylene oxide)-Based Block CopolymersThe Journal of Physical Chemistry B, 2002
- Amphiphilic block copolymer nanocontainers as bioreactorsThe European Physical Journal E, 2001
- Giant Free-Standing ABA Triblock Copolymer MembranesLangmuir, 2000
- Controlled Patterning of Diblock Copolymers by Monolayer Langmuir−Blodgett DepositionMacromolecules, 2000
- Formation and Structure of Self-Assembled MonolayersChemical Reviews, 1996
- Molecular Architecture and Function of Polymeric Oriented Systems: Models for the Study of Organization, Surface Recognition, and Dynamics of BiomembranesAngewandte Chemie-International Edition, 1988