Antioxidant Intake in Pregnancy in Relation to Wheeze and Eczema in the First Two Years of Life
- 15 January 2005
- journal article
- Published by American Thoracic Society in American Journal of Respiratory and Critical Care Medicine
- Vol. 171 (2), 121-128
- https://doi.org/10.1164/rccm.200402-220oc
Abstract
Two thousand women were recruited for a prospective investigation of the influence of maternal antioxidant intake in pregnancy on the development of asthma and eczema in children. A food frequency questionnaire was used to characterize diet during pregnancy and blood antioxidant levels were measured. Postal questionnaires were used to follow up the 1,924 singleton children born to the cohort at 6, 12, and 24 months of age. There were no associations between maternal antioxidant intake and wheezing symptoms and eczema in the children's first year. In the children's second year, maternal vitamin E intake during pregnancy was negatively associated with wheeze in the absence of a "cold" (p for trend 0.010) and, in children whose mothers were atopic, there was a negative association between maternal vitamin E intake and childhood eczema (p for trend 0.024). Maternal vitamin C intake during pregnancy was positively associated with "ever wheeze" and eczema during the children's second year. This study suggests that maternal dietary antioxidant intakes during pregnancy may modify the risks of developing wheeze and eczema during early childhood. Further follow up of the cohort will determine whether maternal diet during pregnancy is associated with asthma and atopic disease in later childhood.Keywords
This publication has 57 references indexed in Scilit:
- Respiratory symptoms and atopy in children in Aberdeen: questionnaire studies of a defined school population repeated over 35 yearsBMJ, 2004
- Vitamin E inhibits IL-4 gene expression in peripheral blood T cellsEuropean Journal of Immunology, 2002
- Annual report October 1998 to September 1999Thorax, 2000
- Dietary intake of antioxidant (pro)-vitamins, respiratory symptoms and pulmonary function: the MORGEN studyThorax, 1998
- Continuing increase in respiratory symptoms and atopy in Aberdeen schoolchildrenBMJ, 1996
- Dietary antioxidant vitamin intake and lung function in the general population.American Journal of Respiratory and Critical Care Medicine, 1995
- Increase in asthma: a more toxic environment or a more susceptible population?Thorax, 1994
- Relationship between dietary vitamin C intake and pulmonary function in the First National Health and Nutrition Examination Survey (NHANES I)The American Journal of Clinical Nutrition, 1994
- A Community-based Study of the Epidemiology of Asthma: Incidence Rates, 1964–1983American Review of Respiratory Disease, 1992
- Respiratory symptoms and atopy in Aberdeen schoolchildren: evidence from two surveys 25 years apart.BMJ, 1992