The salient characteristics of the central effects of acupuncture needling: Limbic‐paralimbic‐neocortical network modulation
- 20 June 2008
- journal article
- research article
- Published by Wiley in Human Brain Mapping
- Vol. 30 (4), 1196-1206
- https://doi.org/10.1002/hbm.20583
Abstract
Human and animal studies suggest that acupuncture produces many beneficial effects through the central nervous system. However, the neural substrates of acupuncture actions are not completely clear to date. fMRI studies at Hegu (LI4) and Zusanli (ST36) indicated that the limbic system may play an important role for acupuncture effects. To test if this finding applies to other major classical acupoints, fMRI was performed on 10 healthy adults during manual acupuncture at Taichong (LV3), Xingjian (LV2), Neiting (ST44), and a sham point on the dorsum of the left foot. Although certain differences could be observed between real and sham points, the hemodynamic response (BOLD signal changes) and psychophysical response (sensory experience) to acupuncture were generally similar for all four points. Acupuncture produced extensive deactivation of the limbic‐paralimbic‐neocortical system. Clusters of deactivated regions were seen in the medial prefrontal cortex (frontal pole, pregenual cingulate), the temporal lobe (amygdala, hippocampus, and parahippocampus) and the posterior medial cortex (precuneus, posterior cingulate). The sensorimotor cortices (somatosensory cortices, supplementary motor cortex), thalamus and occasional paralimbic structures such as the insula and anterior middle cingulate cortex showed activation. Our results provide additional evidence in support of previous reports that acupuncture modulates the limbic‐paralimbic‐neocortical network. We hypothesize that acupuncture may mediate its antipain, antianxiety, and other therapeutic effects via this intrinsic neural circuit that plays a central role in the affective and cognitive dimensions of pain as well as in the regulation and integration of emotion, memory processing, autonomic, endocrine, immunological, and sensorimotor functions. Hum Brain Mapp, 2009.Keywords
This publication has 55 references indexed in Scilit:
- Hypothalamus and amygdala response to acupuncture stimuli in carpal tunnel syndromePain, 2007
- Test–retest study of fMRI signal change evoked by electroacupuncture stimulationNeuroImage, 2007
- Coherent Spontaneous Activity Identifies a Hippocampal-Parietal Memory NetworkJournal of Neurophysiology, 2006
- Retraction for Cho et al., New findings of the correlation between acupoints and corresponding brain cortices using functional MRIProceedings of the National Academy of Sciences of the United States of America, 2006
- Neural substrates, experimental evidences and functional hypothesis of acupuncture mechanismsActa Neurologica Scandinavica, 2006
- The precuneus: a review of its functional anatomy and behavioural correlatesBrain, 2006
- Acupoint-specific fMRI patterns in human brainNeuroscience Letters, 2005
- Neuronal Specificity of Acupuncture Response: A fMRI Study with ElectroacupunctureNeuroImage, 2002
- A Pilot Study of Functional Magnetic Resonance Imaging of the Brain During Manual and Electroacupuncture Stimulation of Acupuncture Point (LI-4 Hegu) in Normal Subjects Reveals Differential Brain Activation Between MethodsThe Journal of Alternative and Complementary Medicine, 2002
- Acupuncture Produces Central Activations in Pain RegionsNeuroImage, 2001