Umbilical cord blood transplantation: the first 25 years and beyond
Top Cited Papers
Open Access
- 25 July 2013
- journal article
- review article
- Published by American Society of Hematology in Blood
- Vol. 122 (4), 491-498
- https://doi.org/10.1182/blood-2013-02-453175
Abstract
Umbilical cord blood is an alternative hematopoietic stem cell source for patients with hematologic diseases who can be cured by allogeneic hematopoietic cell transplantation. Initially, umbilical cord blood transplantation was limited to children, given the low cell dose infused. Both related and unrelated cord blood transplants have been performed with high rates of success for a variety of hematologic disorders and metabolic storage diseases in the pediatric setting. The results for adult umbilical cord blood transplantation have improved, with greater emphasis on cord blood units of sufficient cell dose and human leukocyte antigen match and with the use of double umbilical cord blood units and improved supportive care techniques. Cord blood expansion trials have recently shown improvement in time to engraftment. Umbilical cord blood is being compared with other graft sources in both retrospective and prospective trials. The growth of the field over the last 25 years and the plans for future exploration are discussed.Keywords
This publication has 100 references indexed in Scilit:
- Ex vivo fucosylation improves human cord blood engraftment in NOD-SCID IL-2Rγnull miceExperimental Hematology, 2012
- Serious Infection Risk and Immune Recovery after Double-Unit Cord Blood Transplantation Without Antithymocyte GlobulinTransplantation and Cellular Therapy, 2011
- Umbilical Cord Blood Transplantation for Children with Thalassemia and Sickle Cell DiseaseTransplantation and Cellular Therapy, 2011
- Reduced Late Mortality Risk Contributes to Similar Survival after Double-Unit Cord Blood Transplantation Compared with Related and Unrelated Donor Hematopoietic Stem Cell TransplantationTransplantation and Cellular Therapy, 2011
- Ex vivo rapamycin treatment of human cord blood CD34+ cells enhances their engraftment of NSG miceBlood Cells, Molecules, and Diseases, 2011
- Availability of Cord Blood Extends Allogeneic Hematopoietic Stem Cell Transplant Access to Racial and Ethnic MinoritiesTransplantation and Cellular Therapy, 2010
- Donor-Derived Second Hematologic Malignancies after Cord Blood TransplantationTransplantation and Cellular Therapy, 2010
- Defining the Intensity of Conditioning Regimens: Working DefinitionsTransplantation and Cellular Therapy, 2009
- Reduced-Intensity Conditioning Regimen Workshop: Defining the Dose Spectrum. Report of a Workshop Convened by the Center for International Blood and Marrow Transplant ResearchTransplantation and Cellular Therapy, 2009
- Double Unrelated Reduced-Intensity Umbilical Cord Blood Transplantation in AdultsTransplantation and Cellular Therapy, 2007