Selection during Cefepime Treatment of a New Cephalosporinase Variant with Extended-Spectrum Resistance to Cefepime in an Enterobacter aerogenes Clinical Isolate
Open Access
- 1 March 2004
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 48 (3), 1040-1042
- https://doi.org/10.1128/aac.48.3.1040-1042.2004
Abstract
Enterobacter aerogenes resistant to cefepime (MIC, 32 μg/ml) was isolated from a patient treated with cefepime for an infection caused by a strain of E. aerogenes overproducing its AmpC β-lactamase (MIC of cefepime, 0.5 μg/ml). The AmpC β-lactamase of the resistant strain had an L-293-P amino acid substitution and a high k cat / K m ratio for cefepime. Both of these modifications were necessary for resistance to cefepime.Keywords
This publication has 11 references indexed in Scilit:
- Mutational Replacement of Leu-293 in the Class C Enterobacter cloacae P99 β-Lactamase Confers Increased MIC of CefepimeAntimicrobial Agents and Chemotherapy, 2002
- Extension of resistance to cefepime and cefpirome associated to a six amino acid deletion in the H-10 helix of the cephalosporinase of anEnterobacter cloacaeclinical isolateFEMS Microbiology Letters, 2001
- Nucleotide Sequence of the Chromosomal ampC Gene of Enterobacter aerogenesAntimicrobial Agents and Chemotherapy, 2000
- TEM-24 extended-spectrum β-lactamase-producing Enterobacter aerogenes: long-term clonal dissemination in French hospitalsClinical Microbiology & Infection, 2000
- An extended-spectrum AmpC-type β-lactamase obtained by in vitro antibiotic selectionFEMS Microbiology Letters, 1998
- Efficacy of Cefepime in the Treatment of Infections Due to Multiply Resistant Enterobacter SpeciesClinical Infectious Diseases, 1996
- Factors involved in the enhanced efficacy against Gram-negative bacteria of fourth generation cephalosporinsJournal of Antimicrobial Chemotherapy, 1992
- β-Lactamase expression and outer membrane protein changes in cefpirome-resistant and ceftazidime-resistant Gram-negative bacteriaJournal of Antimicrobial Chemotherapy, 1991
- Regulation of enterobacterial cephalosporinase production: the role of a membrane‐bound sensory transducerMolecular Microbiology, 1989
- Comparison of a new cephalosporin, BMY 28142, with other broad-spectrum beta-lactam antibioticsAntimicrobial Agents and Chemotherapy, 1985