Cross-Presentation, Dendritic Cells, Tolerance and Immunity
- 1 April 2001
- journal article
- review article
- Published by Annual Reviews in Annual Review of Immunology
- Vol. 19 (1), 47-64
- https://doi.org/10.1146/annurev.immunol.19.1.47
Abstract
This review examines the role of cross-presentation in tolerance and immunity. We discuss (a) the antigenic requirements for cross-presentation, (b) the phenotype of the antigen presenting cell (APC), (c) the cellular interactions and molecular signals involved in cross-priming, and (d) the factors that direct the immune system toward tolerance or immunity. A large part of this review is dedicated to summarizing our current knowledge of the cross-presenting APC.Keywords
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