The post‐thrombotic syndrome: progress and pitfalls
- 18 July 2006
- journal article
- review article
- Published by Wiley in British Journal of Haematology
- Vol. 134 (4), 357-365
- https://doi.org/10.1111/j.1365-2141.2006.06200.x
Abstract
The post-thrombotic syndrome (PTS) develops in up to one half of patients after symptomatic deep venous thrombosis (DVT) and is the most common complication of DVT. Typical features of PTS include chronic pain, swelling, heaviness, oedema and skin changes in the affected limb. In severe cases, venous ulcers may develop. The frequency of PTS is likely to be reduced by preventing DVT with the use of effective thromboprophylaxis in high-risk patients and settings and by minimising the risk of ipsilateral DVT recurrence. Use of compression stockings for 2 years after DVT appears to reduce the incidence and severity of PTS but issues remain regarding their use and effectiveness. Future research should focus on elucidating the pathophysiology and risk factors for PTS, assessing the safety and effectiveness of catheter-directed thrombolysis to prevent PTS and evaluating the optimal use of compression stockings to prevent and treat PTS. In addition, new therapies to treat PTS should be sought and evaluated.Keywords
This publication has 65 references indexed in Scilit:
- Post‐thrombotic syndrome, recurrence, and death 10 years after the first episode of venous thromboembolism treated with warfarin for 6 weeks or 6 monthsJournal of Thrombosis and Haemostasis, 2006
- The post-thrombotic syndrome: risk factors and impact on the course of thrombotic diseaseJournal of Thrombosis and Haemostasis, 2005
- Vein abnormalities and the post‐thrombotic syndromeJournal of Thrombosis and Haemostasis, 2005
- Long-Term Management of Patients After Venous ThromboembolismCirculation, 2004
- Randomised trial of effect of compression stockings in patients with symptomatic proximal-vein thrombosisThe Lancet, 1997
- Comparison of leg compression stocking and oral horse-chestnut seed extract therapy in patients with chronic venous insufficiencyThe Lancet, 1996
- A study of the impact of leg ulcers on quality of life: Financial, social, and psychologic implicationsJournal of the American Academy of Dermatology, 1994
- Long‐term Sequelae of Calf Vein Thrombosis Treated with Heparin or Low‐dose StreptokinaseActa Medica Scandinavica, 1986
- Efficacy of graded elastic compression in the lower legPublished by American Medical Association (AMA) ,1983
- Streptokinase or Heparin in the Treatment of Deep Vein ThrombosisActa Medica Scandinavica, 1982