Mycophenolate Mofetil in Lupus Glomerulonephritis
- 27 September 2007
- journal article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 1110 (1), 516-524
- https://doi.org/10.1196/annals.1423.055
Abstract
Mycophenolate mofetil (MMF) is an immunosuppressive agent initially used in the treatment of transplant recipients. MMF has been used in renal, heart, and liver transplantation, where it seems more effective than other immunosuppressive regimens in reducing the incidence of acute rejection episodes. MMF has a variety of immunosuppressive effects, including selective suppression of T and B lymphocyte proliferation, and has been more recently used in many autoimmune inflammatory conditions. Systemic lupus erythematosus (SLE) is an autoimmune disease that can potentially involve any organ or system of the human body. Glomerulonephritis (GLN) has been recognized as the most frequent severe manifestation of SLE, leading to poor long-term prognosis. In the treatment of lupus GLN, several therapeutic approaches, all including immunosuppressive drugs, such as cyclophosphamide, azathioprine, or cyclosporine A, have been used. The short- and long-term toxicity of these drugs limits their use in a substantial number of patients. Over the last few years, MMF has emerged as an alternative therapeutic regimen in lupus GLN, mainly for patients refractory to other therapies. These studies have shown that it is highly effective and generally well tolerated.Keywords
This publication has 33 references indexed in Scilit:
- Urinary TWEAK and the activity of lupus nephritisJournal of Autoimmunity, 2006
- Mycophenolate mofetil and systemic lupus erythematosusLupus, 2006
- Role of anti-DNA antibodies in the pathogenesis of lupus nephritisAutoimmunity Reviews, 2006
- Urinary biomarkers in lupus nephritisAutoimmunity Reviews, 2006
- Quality of life comparison between corticosteroidand-mycofenolate mofetil and corticosteroidand-oral cyclophosphamide in the treatment of severe lupus nephritisLupus, 2006
- The role of complement in autoimmune renal diseaseAutoimmunity, 2006
- Non-Hodgkin's lymphoma in systemic lupus erythematosusAnnals Of The Rheumatic Diseases, 2005
- Lupus nephritis: treatment with mycophenolate mofetilRheumatology, 2003
- Primary brain lymphomas after kidney transplantation: presentation and outcomeTransplantation, 2003
- Mycophenolate mofetil in cadaveric renal transplantationAmerican Journal of Kidney Diseases, 1999