Localization of the c-abl oncogene adjacent to a translocation break point in chronic myelocytic leukaemia
- 1 November 1983
- journal article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 306 (5940), 239-242
- https://doi.org/10.1038/306239a0
Abstract
The human c-ab1 oncogene maps within the region (q34-qter) of chromosome 9 which is translocated to chromosome 22, the Philadelphia (Ph') chromosome, in chronic myelocytic leukaemia (CML). The position of the Ph' chromosomal break point is shown to be variable and, in one CML patient, has been localized immediately 5' of, or within, the c-ab1 oncogene. A DNA restriction fragment corresponding to this site has been molecularly cloned and shown to represent a chimaeric fragment of DNA from chromosomes 9 and 22.This publication has 31 references indexed in Scilit:
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