The non-motor syndrome of primary dystonia: clinical and pathophysiological implications
Open Access
- 20 September 2011
- journal article
- review article
- Published by Oxford University Press (OUP) in Brain
- Vol. 135 (6), 1668-1681
- https://doi.org/10.1093/brain/awr224
Abstract
Dystonia is typically considered a movement disorder characterized by motor manifestations, primarily involuntary muscle contractions causing twisting movements and abnormal postures. However, growing evidence indicates an important non-motor component to primary dystonia, including abnormalities in sensory and perceptual functions, as well as neuropsychiatric, cognitive and sleep domains. Here, we review this evidence and discuss its clinical and pathophysiological implications.Keywords
This publication has 189 references indexed in Scilit:
- Neurophysiology of dystonia: The role of inhibitionNeurobiology of Disease, 2011
- Nonmotor manifestations of dystonia: A systematic reviewMovement Disorders, 2011
- Cerebellothalamocortical pathway abnormalities in torsinA DYT1 knock-in miceProceedings of the National Academy of Sciences of the United States of America, 2011
- In vivo neurochemistry of primary focal hand dystonia: A magnetic resonance spectroscopic neurometabolite profiling study at 3TMovement Disorders, 2010
- Convergent evidence for abnormal striatal synaptic plasticity in dystoniaNeurobiology of Disease, 2010
- Imaging phenotypes of major depressive disorder: genetic correlatesNeuroscience, 2009
- Genotype–phenotype interactions in primary dystonias revealed by differential changes in brain structureNeuroImage, 2009
- The Pathophysiology of Focal Hand DystoniaJournal of Hand Therapy, 2009
- A meta‐analytic study of changes in brain activation in depressionHuman Brain Mapping, 2007
- Intragenic Cis and Trans Modification of Genetic Susceptibility in DYT1 Torsion DystoniaAmerican Journal of Human Genetics, 2007