Abnormal glucose tolerance and insulin secretion in pancreas-specific Tcf7l2-null mice
Open Access
- 21 June 2012
- journal article
- research article
- Published by Springer Science and Business Media LLC in Diabetologia
- Vol. 55 (10), 2667-2676
- https://doi.org/10.1007/s00125-012-2600-7
Abstract
Individuals carrying type 2 diabetes risk alleles in TCF7L2 display decreased beta cell levels of T cell factor 7 like-2 (TCF7L2) immunoreactivity, and impaired insulin secretion and beta cell sensitivity to glucagon-like peptide 1 (GLP-1). Here, we sought to determine whether selective deletion of Tcf7l2 in mouse pancreas impairs insulin release and glucose homeostasis.Keywords
This publication has 54 references indexed in Scilit:
- An alternative polyadenylation signal in TCF7L2 generates isoforms that inhibit T cell factor/lymphoid-enhancer factor (TCF/LEF)-dependent target genesDiabetologia, 2011
- Nucleo-cytosolic Shuttling of FoxO1 Directly Regulates Mouse Ins2 but Not Ins1 Gene Expression in Pancreatic Beta Cells (MIN6)Journal of Biological Chemistry, 2011
- Genomics, Type 2 Diabetes, and ObesityThe New England Journal of Medicine, 2010
- Twelve type 2 diabetes susceptibility loci identified through large-scale association analysisNature Genetics, 2010
- A map of open chromatin in human pancreatic isletsNature Genetics, 2010
- Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challengeNature Genetics, 2010
- Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphismsDiabetologia, 2007
- Wnt signaling regulates pancreatic β cell proliferationProceedings of the National Academy of Sciences of the United States of America, 2007
- A genome-wide association study identifies novel risk loci for type 2 diabetesNature, 2007
- Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetesNature Genetics, 2006