Synergistic Activities of Fluconazole and Voriconazole with Terbinafine against Four Candida Species Determined by Checkerboard, Time-Kill, and Etest Methods

Abstract
The in vitro activities of fluconazole or voriconazole plus terbinafine were evaluated against 20 Candida isolates by the checkerboard, time-kill, and Etest methods. Synergism ( C. albicans , C. glabrata , and C. tropicalis ) and indifference ( C. krusei ) were observed. Correlation among methods was good. The Etest is a suitable method to determine drug interactions.