ANALYSIS OF THE DIFFERENTIATION AND OF THE HETEROGENEITY WITHIN A POPULATION OF ESCHERICHIA COLI UNDERGOING INDUCED β-GALACTOSIDASE SYNTHESIS
Open Access
- 1 November 1959
- journal article
- research article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 78 (5), 613-623
- https://doi.org/10.1128/jb.78.5.613-623.1959
Abstract
When the metabolic Activity of a system under induction is essential to the formation of that system, the response of each cell in a population is sharply dependent upon whether it possesses a minimum unit of the induced activity. As a result, the formation of enzyme by the population is heterogenous. Both the formation and nonformation of enzyme is passed on clonally to the descendants. Two induced systems: the galactoside-permease and [beta]-galactosidase (Cohen and Monod, 1957) of E. coli and the galactozymase of long-term adapting yeast (Spiegelman, 1951) can be understood in terms of this concept for which experimental evidence is presented.Keywords
This publication has 18 references indexed in Scilit:
- On the behavior of the E. coli Pz-“β-galactoside system” introduced into Shigella dysenteriaeBiochimica et Biophysica Acta, 1960
- INHIBITION BY GLUCOSE OF THE INDUCED SYNTHESIS OF THE β-GALACTOSIDE-ENZYME SYSTEM OF ESCHERICHIA COLI . ANALYSIS OF MAINTENANCEJournal of Bacteriology, 1959
- Studies on the induction of β-galactosidase in a cryptic strain of Escherichia coliBiochimica et Biophysica Acta, 1959
- ENZYME INDUCTION AS AN ALL-OR-NONE PHENOMENONProceedings of the National Academy of Sciences, 1957
- Induced synthesis of enzymes in bacteria analyzed at the cellular levelBiochimica et Biophysica Acta, 1953
- Substrate Stabilization of Enzyme-Forming Capacity During the Segregation of a HeterozygoteProceedings of the National Academy of Sciences of the United States of America, 1952
- La cinétique de la biosynthèse de la β-galactosidase chez E. coli considérée comme fonction de la croissanceBiochimica et Biophysica Acta, 1952
- A Single-Cell Analysis of the Transmission of Enzyme-Forming Capacity in YeastProceedings of the National Academy of Sciences of the United States of America, 1951
- THE PARTICULATE TRANSMISSION OF ENZYME-FORMING CAPACITY IN YEASTCold Spring Harbor Symposia on Quantitative Biology, 1951
- On the Cytoplasmic Nature of “Long-Term Adaptation” in YeastProceedings of the National Academy of Sciences of the United States of America, 1950