RIGOR Guidelines: Escalating STAIR and STEPS for Effective Translational Research
Open Access
- 5 September 2012
- journal article
- review article
- Published by Springer Science and Business Media LLC in Translational Stroke Research
- Vol. 4 (3), 279-285
- https://doi.org/10.1007/s12975-012-0209-2
Abstract
Stroke continues to be a serious and significant health problem in the USA and worldwide. This article will emphasize the need for good laboratory practices, transparent scientific reporting, and the use of translational research models representative of the disease state to develop effective treatments. This will allow for the testing and development of new innovative strategies so that efficacious therapies can be developed to treat ischemic and hemorrhagic stroke. This article recommends guidelines for effective translational research, most importantly, the need for study blinding, study group randomization, power analysis, accurate statistical analysis, and a conflict of interest statement. Additional guidelines to ensure reproducibility of results and confirmation of efficacy in multiple species are discussed.Keywords
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