Biphenotypic MO Acute Myeloid Leukemia with Trisomy-4
- 1 January 1994
- journal article
- case report
- Published by Informa UK Limited in Leukemia & Lymphoma
- Vol. 14 (1-2), 181-184
- https://doi.org/10.3109/10428199409049666
Abstract
We report here a rare case of biphenotypic MO acute myeloid leukemia (AML) associated with trisomy 4. The literature of trisomy 4 in acute leukemia was reviewed. M2 and M4 AML are the most common FAB subtypes associated with trisomy 4. The clinical course of this entity is generally comparable with other non-trisomy 4 cases of AML. Despite the speculation made when first described, no specific environmental toxin has been found to be associated with this entity. C-kit oncogene has been mapped to chromosome 4 recently, and the role of this proto-oncogene in leukemogenesis of trisomy 4 associated leukemia should be further investigated.Keywords
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