Dually Responsive Injectable Hydrogel Prepared by In Situ Cross-Linking of Glycol Chitosan and Benzaldehyde-Capped PEO-PPO-PEO
- 25 March 2010
- journal article
- research article
- Published by American Chemical Society (ACS) in Biomacromolecules
- Vol. 11 (4), 1043-1051
- https://doi.org/10.1021/bm1000179
Abstract
Injectable hydrogels with pH and temperature triggered drug release capability were synthesized based on biocompatible glycol chitosan and benzaldehyde-capped poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) (PEO-PPO-PEO). Aqueous solutions of the above polymers formed hydrogel under physiological conditions, allowing a desirable injectability, through the formation covalent benzoic-imine bond with pH and temperature changes. Rheological characterization demonstrated that the gelation rate and the moduli of the hydrogels were able to be tuned with chemical composition as well as pH and temperature of the polymer solution. Both hydrophobic and hydrophilic drugs could be incorporated inside the hydrogel through the in situ gel forming process and undergo a controlled release by altering pH or temperature. In vivo tests proved the formation and biocompatibility of the hydrogel in rat model.Keywords
This publication has 36 references indexed in Scilit:
- pH-triggered injectable hydrogels prepared from aqueous N-palmitoyl chitosan: In vitro characteristics and in vivo biocompatibilityBiomaterials, 2009
- A study of thermoassociative gelation of aqueous cationic poly(N-isopropyl acrylamide) graft copolymer solutionsPolymer, 2009
- Designing Temperature-Responsive Biocompatible Copolymers and Hydrogels Based on 2-Hydroxyethyl(meth)acrylatesBiomacromolecules, 2008
- pH/temperature sensitive poly(ethylene glycol)-based biodegradable polyester block copolymer hydrogelsPolymer, 2006
- Novel Injectable pH and Temperature Sensitive Block Copolymer HydrogelBiomacromolecules, 2005
- In situ-forming hydrogels—review of temperature-sensitive systemsEuropean Journal of Pharmaceutics and Biopharmaceutics, 2004
- ABA-triblock copolymers from biodegradable polyester A-blocks and hydrophilic poly(ethylene oxide) B-blocks as a candidate for in situ forming hydrogel delivery systems for proteinsAdvanced Drug Delivery Reviews, 2001
- Hydrogels for biomedical applicationsAdvanced Drug Delivery Reviews, 2001
- Environment-sensitive hydrogels for drug deliveryAdvanced Drug Delivery Reviews, 2001
- Biodegradable block copolymers as injectable drug-delivery systemsNature, 1997