Porcine ear skin: an in vitro model for human skin
Top Cited Papers
- 14 December 2006
- journal article
- research article
- Published by Wiley in Skin Research and Technology
- Vol. 13 (1), 19-24
- https://doi.org/10.1111/j.1600-0846.2006.00179.x
Abstract
Background/purpose: Porcine ear skin is used in studies of percutaneous penetration as a substitute for human skin. The structure of this tissue, including hair follicles, was studied qualitatively and quantitatively in comparison with human skin. Methods: Sections of shock‐frozen biopsies, biopsies embedded in paraffin and cyanoacrylate skin surface biopsies were investigated using microscopy. The thickness of the different skin layers and the follicular characteristics were determined. Results: The thickness of the stratum corneum was 17–28 μm, whereas the viable epidermis was 60–85 μm thick. On 1 cm2, 11–25 hairs were detected, showing a diameter of 58–97 μm and a maximal extension depth of 0.96–1.38 mm into the skin. The orifices of the porcine infundibula showed a diameter of approximately 200 μm. Conclusions: The results obtained are similar to those of human skin, indicating the suitability of this porcine tissue as a model for human skin.This publication has 23 references indexed in Scilit:
- The porcine snout – an in vitro model for human lips?Experimental Dermatology, 2005
- Penetration von Pollenallergenen durch die Haut - Entwicklung einer neuen NachweismethodeAktuelle Dermatologie, 2003
- Percutaneous Absorption of Sunscreens in vitro: Interspecies Comparison, Skin Models and Reproducibility AspectsSkin Pharmacology and Physiology, 2000
- Comparative Biomembrane Permeation of Tacrine Using Yucatan Minipigs and Domestic Pigs as the Animal ModelJournal of Pharmaceutical Sciences, 1998
- Distribution of Hairs and Sweat Glands on the Bodies of Korean Adults: A Morphometric StudyCells Tissues Organs, 1997
- Dermal absorption of polycyclic aromatic hydrocarbons in the blood‐perfused pig earJournal of Applied Toxicology, 1995
- Percutaneous absorption of hexachlorophene in rats, guinea pigs and pigsToxicology, 1978
- Regional Variation in Percutaneous Penetration of 14C Cortisol in Man**From the Division of Dermatology, Department of Medicine, University of California School of Medicine, San Francisco, California 94122.Journal of Investigative Dermatology, 1967
- Mechanism of Percutaneous AbsorptionJournal of Investigative Dermatology, 1967