Cracking the survival code
- 14 January 2014
- journal article
- review article
- Published by Taylor & Francis Ltd in Autophagy
- Vol. 10 (4), 556-561
- https://doi.org/10.4161/auto.27280
Abstract
Modifications of histones, the chief protein components of the chromatin, have emerged as critical regulators of life and death. While the apoptotic histone code came to light a few years ago, accumulating evidence indicates that autophagy, a cell survival pathway, is also heavily regulated by histone-modifying proteins. In this review we describe the emerging autophagic histone code and the role of histone modifications in the cellular life vs. death decision.Keywords
This publication has 60 references indexed in Scilit:
- Gossypol and an HMT G9a inhibitor act in synergy to induce cell death in pancreatic cancer cellsCell Death & Disease, 2013
- FOXP3 Orchestrates H4K16 Acetylation and H3K4 Trimethylation for Activation of Multiple Genes by Recruiting MOF and Causing Displacement of PLU-1Molecular Cell, 2011
- Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone ModificationCell, 2011
- Recognition of a Mononucleosomal Histone Modification Pattern by BPTF via Multivalent InteractionsCell, 2011
- Genome-wide Mapping of HATs and HDACs Reveals Distinct Functions in Active and Inactive GenesCell, 2009
- Autophagy in the Pathogenesis of DiseaseCell, 2008
- Chromatin Modifications and Their FunctionCell, 2007
- Methylation of Lysine 4 on Histone H3: Intricacy of Writing and Reading a Single Epigenetic MarkMolecular Cell, 2007
- Histone Demethylation Mediated by the Nuclear Amine Oxidase Homolog LSD1Cell, 2004
- The language of covalent histone modificationsNature, 2000